ea0099p596 | Late-Breaking | ECE2024
Hassany Mariam
, Warde Kate
, Feely Sarah
, Cantini Giulia
, Propato Arianna
, Galtarossa Luca
, Luconi Michaela
, Dennedy Michael
Management of ACC is difficult. Diagnosis usually occurs at an advanced disease stage. Resection of localised disease offers a potential cure, but recurrence is common (75-85% of cases). For the treatment of unresectable/metastatic disease, mitotane is the only approved drug, alongside M-EDP chemotherapy. Mitotane has a narrow therapeutic window and is poorly tolerated. Additionally, ACC is a heterogenous disease regarding phenotype, genotype, disease progression and resistanc...